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In 1997 Ryan was chosen for a role on the science fiction series Star Trek: Voyager as Seven of Nine, a Borg drone who had been "liberated", or freed, from the Borg's collective consciousness. Ryan appeared in the romantic comedy film Down with Love and she guest-starred as Courtney Reece on David E. Ryan then co-starred in the CBS legal drama Shark as Los Angeles County District Attorney Jessica Devlin alongside series lead James Woods, but she did not return for episodes aired after the 2007–2008 Writers Guild of America strike, although she was credited in all four episodes.